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A one-pot, whole-cell biocatalysis approach for vanillin production using lignin oil
Vanillin is a popular and versatile flavor compound, almost entirely produced from petroleum-derived phenol by a multi-step chemical …
Ivana Maric
,
Yiming Guo
,
Maximilian JLJ Fürst
,
Korneel van Aelst
,
Sander van den Bosch
,
Mario de Simone
,
Ligia Martins
,
Bert Sels
,
Marco Fraaije
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DOI
Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening
Developing therapeutic antibodies is laborious and costly. Here we report a method for antibody discovery that leverages the Illumina …
Benjamin T. Porebski
,
Matthew Balmforth
,
Gareth Browne
,
Aidan Riley
,
Kiarash Jamali
,
Maximilian JLJ Fürst
,
Mirko Velic
,
Andrew Buchanan
,
Ralph Minter
,
Tristan Vaughan
,
hilipp Holliger
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DOI
Curse and Blessing of Non-proteinogenic Parts in Computational Enzyme Engineering
Enzyme engineering aims to improve or install a new function in biocatalysts for applications ranging from chemical synthesis to …
Kerlen T. Korbeld
,
Maximilian JLJ Fürst
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DOI
The Expanded Central Dogma: Genome Resynthesis, Orthogonal Biosystems, Synthetic Genetics
Synthetic biology seeks to probe fundamental aspects of biological form and function by construction [i.e., (re)synthesis] rather than …
Karola Gerecht
,
Niklas Freund
,
Wei Liu
,
Yang Liu
,
Maximilian JLJ Fürst
,
Philipp Holliger
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DOI
New chemistries and enzymes for synthetic genetics
Beyond the natural nucleic acids DNA and RNA, nucleic acid chemistry has unlocked a whole universe of modifications to their canonical …
Niklas Freund
,
Maximilian JLJ Fürst
,
Philipp Holliger
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DOI
Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases
Monooxygenases (MOs) face the challenging reaction of an organic target, oxygen and a cofactor – most commonly heme or flavin. To …
Maximilian JLJ Fürst
,
Filippo Fiorentini
,
Marco W Fraaije
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DOI
Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering
Enzyme instability is an important limitation for the investigation and application of enzymes. Therefore, methods to rapidly and …
Friso S Aalbers
,
Maximilian JLJ Fürst
,
Stefano Rovida
,
Milos Trajkovic
,
J Rubén Gómez Castellanos
,
Sebastian Bartsch
,
Andreas Vogel
,
Andrea Mattevi
,
Marco W Fraaije
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DOI
Baeyer–Villiger monooxygenases: tunable oxidative biocatalysts
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical industry a poor public reputation, despite their …
Maximilian JLJ Fürst
,
Alejandro Gran-Scheuch
,
Friso S Aalbers
,
Marco W Fraaije
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DOI
Exploring the Biocatalytic Potential of a Self‐Sufficient Cytochrome P450 from Thermothelomyces thermophila
Among nature’s arsenal of oxidative enzymes, cytochrome P450s (CYPs) catalyze the most challenging reactions, the hydroxylations …
Maximilian JLJ Fürst
,
Bianca Kerschbaumer
,
Claudia Rinnofner
,
Anna K Migglautsch
,
Margit Winkler
,
Marco W Fraaije
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DOI
Stabilization of cyclohexanone monooxygenase by computational and experimental library design
Enzymes often by far exceed the activity, selectivity, and sustainability achieved with chemical catalysts. One of the main reasons for …
Maximilian JLJ Fürst
,
Marjon Boonstra
,
Selle Bandstra
,
Marco W Fraaije
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