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New chemistries and enzymes for synthetic genetics
Beyond the natural nucleic acids DNA and RNA, nucleic acid chemistry has unlocked a whole universe of modifications to their canonical …
Niklas Freund
,
Maximilian JLJ Fürst
,
Philipp Holliger
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Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases
Monooxygenases (MOs) face the challenging reaction of an organic target, oxygen and a cofactor – most commonly heme or flavin. To …
Maximilian JLJ Fürst
,
Filippo Fiorentini
,
Marco W Fraaije
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Baeyer–Villiger monooxygenases: tunable oxidative biocatalysts
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical industry a poor public reputation, despite their …
Maximilian JLJ Fürst
,
Alejandro Gran-Scheuch
,
Friso S Aalbers
,
Marco W Fraaije
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Side-chain pruning has limited impact on substrate preference in a promiscuous enzyme
Detoxifying enzymes such as flavin-containing monooxygenases deal with a huge array of highly diverse xenobiotics and toxic compounds. …
Maximilian JLJ Fürst
,
Elvira Romero
,
J Rubén Gómez Castellanos
,
Marco W Fraaije
,
Andrea Mattevi
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