Review

New chemistries and enzymes for synthetic genetics
Beyond the natural nucleic acids DNA and RNA, nucleic acid chemistry has unlocked a whole universe of modifications to their canonical …
PDF Cite DOI
Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases
Monooxygenases (MOs) face the challenging reaction of an organic target, oxygen and a cofactor – most commonly heme or flavin. To …
PDF Cite DOI
Baeyer–Villiger monooxygenases: tunable oxidative biocatalysts
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical industry a poor public reputation, despite their …
PDF Cite DOI
Side-chain pruning has limited impact on substrate preference in a promiscuous enzyme
Detoxifying enzymes such as flavin-containing monooxygenases deal with a huge array of highly diverse xenobiotics and toxic compounds. …
PDF Cite DOI